London's vast urban area is often described using a set of district names (e.g. Bloomsbury, Mayfair, Whitechapel). These are either informal designations, or reflect the names of superseded parishes and city wards. Such names have remained in use through tradition, each referring to a neighbourhood with its own distinctive character, but often with no modern official boundaries (the boundaries often overlap, allowing estate agents some leeway in defining the location of a property).

One area of London which does have a strict definition is the City of London (usually just called The City), the largest financial district and central business district (CBD) in Europe. The City has its own governance and boundaries, giving it a status as the only completely autonomous local authority in London. London's new financial and commercial hub is the Docklands area to the east of the City, dominated by the Canary Wharf complex. Other businesses locate in the City of Westminster, the home of the UK's national government and the famous Westminster Abbey (NOT the centre of the Anglican Church, which is at Canterbury).

The West End is London's main entertainment and shopping district, with locations such as Oxford Street, Leicester Square, Covent Garden and Piccadilly Circus acting as tourist magnets. The West London area is known for fashionable and expensive residential areas such as Notting Hill, Kensington and Chelsea - where some properties can sell for £5,000,000 and above.

The eastern side of London contains the East End — the area closest to the original Port of London, known for its high immigrant population, as well as for being one of the poorest areas in London. The surrounding East London area saw much of London's early industrial development; now, brownfield sites throughout the area are being redeveloped, including areas along the Thames (the Thames Gateway) and up the Lower Lea Valley, which is being developed into the Olympic Park for the 2012 Olympics. North London and South London are informal divisions of the capital made by the River Thames, although they can define varying areas.